Twelve of the 76 patients (15.8 %) experienced 18 serious AEs that met criteria defined as DLTs, including four grade 3 palmar-plantar erythrodysaesthesia syndrome, three grade 3 rash, and one each of grade 3 dyspnea, fatigue, hypertension, pain in extremity, dizziness, prolonged prothrombin time/increased international normalized ratio, neutropenia, diarrhea, pneumonia and allodynia. Here, F2 is linked to hypertensive disorder.