Interrupting the β2-M signaling pathway may induce apoptosis in tumor cells and β2-M may stimulate growth and improve osteocalcin (OC) and bone sialoprotein (BSP) gene expression in human prostate cancer cells via activating cyclic AMP (cAMP)-dependent PAK signaling pathway [10, 21]. The gene discussed is IBSP; the disease is Familial prostate cancer.