GRIN2B and schizophrenia: Similar to our study, in cortical brain areas it has been shown that despite no change in [3H] ifenprodil binding [25], there was a reduction in GluN2B protein in schizophrenia compared to control subjects, which was specific to the endoplasmic reticulum [26], suggesting there may be altered production, degradation or trafficking of GluN2B protein in schizophrenia.