SYP and schizophrenia: Several lines of research have shown that there are various structural and functional abnormalities in the hippocampus of schizophrenia patients, including a reduction in hippocampal volume, altered synaptic connections (evidenced through reductions in synaptosomal proteins such as synaptophysin, SNAP-25 and synapsin) and changes in neurotransmitter receptors, implicating the hippocampus in the pathophysiology of schizophrenia [2].