These findings suggest the role of genetic factors in OCM alterations in schizophrenia and are in line with the plethora of studies showing the association between two functional polymorphisms (C677T and A1298C) in the methylenetetrahydrofolate reductase (MTHFR) gene and schizophrenia risk [12, 13]. The gene discussed is MTHFR; the disease is schizophrenia.