We speculate that, under normal conditions, AnxA2 is involved in physiological COL1A2 regulation to prevent excessive deposition of type I collagen which is characteristic of many fibrotic disorders such as systemic sclerosis, hepatic cirrhosis and pulmonary fibrosis [Varga and Jimenez, 1995]. The gene discussed is COL1A2; the disease is pulmonary fibrosis.