When we macro-dissected tumors from these mice and performed qPCR for Rgs5 expression (Fig. 2E, F), we found that Rgs5 expression mirrored collagen deposition: 1) Rgs5 is elevated in fibrotic Tsc1fl/fl;AlbCre tumors but not adjacent non-fibrotic liver; 2) Rgs5 is elevated in both tumor and surrounding liver (both fibrotic) in Ptenfl/fl;AlbCre mice. The gene discussed is RGS5; the disease is neoplasm.