Notably, four of the differentially expressed proteins identified (namely APOA1, B2M, TF, and TTR) are the four serum proteins used with CA125 in the Ova1 diagnostic test 6, 10, 27, approved for use in combination with physician assessment to determine if an ovarian tumour on ultrasound warrants referral for surgery. This evidence concerns the gene B2M and ovarian neoplasm.