These results suggest that 1) the establishment of the enteropathy was dependent on the generation of IL-4-producing CD4+ T-cells in GALT; 2) long-term feeding of EW diet induced CD4+ T-cell tolerance through inhibition of IL-4 production in an OVA-specific manner; and 3) the induction of T-cell tolerance was followed by attenuation of intestinal inflammation and weight loss in EW-fed OVA23-3 mice. The gene discussed is CD4; the disease is Abnormal intestine morphology.