PNPLA3 and metabolic dysfunction-associated steatotic liver disease: But we did not observe significant differences in plasma concentration of these transaminases among wild homozygote genotype, heterozygote genotype and variant homozygote genotype, even when independent of genetic variation in PNPLA3. We also found that the G-allele of the PNPLA3 rs738409 SNP increased the susceptibility to NAFLD independent of SUA in Uygur and Han ethnic groups.