PNPLA3 and metabolic dysfunction-associated steatotic liver disease: From this perspective, based on the PNPLA3 rs738409 G allele frequency of 43% in Han population and 42% in Uygur ethnic, we estimate that the effect of PNPLA3 rs738409 polymorphisms in Asians will confer a much higher genetic susceptibility to NAFLD than in Europeans and Africans.