After adjusted for confounding factors (sex, age, BMI Stage, BP Stage, GLU Stage, TG Stage, TC Stage, LDL Stage, Hyperuricemia, Smoking Status, Life style, Family History Hypertension, Family History Diabetes, Family History of CHD, CHD, Family History of Cancer), the fitted final multiple logistic regression model revealed that, the variant PNPLA3 rs738409 genotypes CG and GG were independent risk factors for NAFLD (Table 3). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.