SOD1 and amyotrophic lateral sclerosis: Additional mRNA targets of FUS that may be relevant to ALS and FTLD include those encoding SOD1, medium and heavy chains of neurofilament (NEFL, NEFM, NEFH), glutamate transporter (EAAT2), ubiquilin 1 and 2, and the FUS protein itself (Lagier-Tourenne et al., 2012).