In MLS and other cancers, chromosomal translocation events result in aberrant transcription factors, formed by a fusion between the N-terminus of FUS and the DNA-binding domain of an endogenous transcription factor such as CHOP (C/EBP homology protein; Crozat, Aman, Mandahl, & Ron, 1993; Rabbitts et al., 1993), ERG (ETS-related gene; Ichikawa et al., 1994; Panagopoulos et al., 1994; Shing et al., 2003), ATF1 (activation transcription factor 1; Raddaoui et al., 2002; Waters et al., 2000), and BBF2H7 (BBF2 human homolog on chromosome 7; Storlazzi et al., 2003). The gene discussed is CREB3L2; the disease is cancer.