The potential roles of FUS in modulating actin dynamics and functions of the cytoskeleton are intriguing in light of ALS-linked mutations within other actin-binding proteins such as profilin-1 (Wu et al., 2012) and the impairment of axonal transport by ALS-linked proteins such as SOD1 (Cu,Zn-superoxide dismutase 1; Morfini et al., 2009). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.