Along with these challenges, Boulay et al. reported that the deletion of Smad7 in CRC patients had a promising clinical outcome compared with patients with SMAD7 amplification  (31), and Halder et al. found that Smad7-overexpressing FET cells show aggressive colony formation on soft agar and increased tumorigenicity in vivo in comparison with control FET cells (32). Here, SMAD7 is linked to colorectal carcinoma.