Furthermore, in HCC and pericancerous liver tissues from all background groups, no significant differences in the CD4 T cells between the tumor parenchyma and peritumor parenchyma (peritumor parenchyma versus tumor parenchyma: NCH background, 4.1±1.4 vs. 6.4±2.8; CH background, 7.9±1.8 vs. 7.1±1.4; PC background, 10.0±3.3 vs. 7.0±1.9; cirrhosis background, 7.6±2.5 vs 8.1±1.8, all P>0.05) were identified. This evidence concerns the gene CD4 and cyclic hematopoiesis.