CD4 and neoplasm: Furthermore, the average numbers of CD8-positive T cells in tumor parenchyma and tumor stroma were significantly increased, compared with the numbers of CD4-positive cells (CD8 versus CD4: tumor parenchyma, 16±2.5 versus 7.4±0.9, P<0.01; tumor stroma, 32.8±4.2 versus 22±3.6, P<0.05).