The DLBCL-associated network also reveals further regulatory associations between genes and miRNAs; for example, EGFR was found to regulate hsa-miR-21, which targets MYC; hsa-miR-21 was identified to target E2F1, which regulates hsa-miR-17; and TP53 was revealed to regulate hsa-miR-125b (hsa-miR-125b-1 and -2), which targets AKT1. The gene discussed is E2F1; the disease is diffuse large B-cell lymphoma.