Previous Studies have shown that hypermethylation of genes encoding cell cycle inhibitors p15 and p16, the apoptosis regulator death-associated protein kinase, the tumor suppressor Ras association domain-containing protein 1 and suppressor of cytokine signaling 1 (SOCS1) occurs frequently in MM patients (9–14). The gene discussed is SOCS1; the disease is Miyoshi myopathy.