Although this bimodal distribution in tumors has been demonstrated using several gene marker panels (5,14), Yamashita et al (20) doubted the presence of CIMP, claiming that tumor-specific somatic hypermethylation of six genes (MLH1, p16, p14, MGMT, APC and CDH1) was an age-dependent feature and that the distribution of the number of tumors harboring their markers was normal (20). This evidence concerns the gene APC and neoplasm.