The overexpression of Her-2 was significantly correlated with the depth of invasion, lymph node metastasis and TNM stage (P<0.05), and no significant correlation was identified between the overexpression of Her-2 and age, gender, tumor location, differentiation degree and Lauren classification (P>0.05; Table I). Here, ERBB2 is linked to metastatic malignant neoplasm in the lymph nodes.