The AKT2 mRNA expression was negatively correlated with let-7b/g expression (let-7b, P = 0.001; let-7g, P = 0.021; Figure 4E), suggesting let-7b/g downregulation might be, at least partly, responsible for the aberrant activation of AKT2 in gastric cancers. The gene discussed is AKT2; the disease is gastric cancer.