The pooled results indicated that there were obvious associations between CHRNA3 rs6495309 polymorphism and lung cancer in Chinese under all models: allele contrast (C vs. T), homozygote (CC vs. TT), heterozygote (CT vs. TT), dominant (CC + CT vs. CC) and recessive (TT vs. CT + CC) model. This evidence concerns the gene CHRNA3 and lung cancer.