Comparison of TP53 mutation profiles in cases with unmutated immunoglobulin heavy chain gene (IGHV; U-CLL) vs mutated IGHV (M-CLL) showed no difference in mutation frequency within sequence motif (RGYW/WRCY) recognized by activation-induced cytidin deaminase in U-CLL vs M-CLL (20 vs 18% of point mutations P=0.8). This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.