The mutations analyzed consisted of 16 missense mutations, 2 non-sense mutations and 2 deletions and were hence representative of the p53 mutation profile in CLL.24 To decipher TP53 mutagenesis, we sequenced not only the affected regions but also all commonly mutated exons 4–9 (ref. 24) with a high median coverage for the positions containing mutations (25 709 reads; range 5245–64 979). The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.