Moreover, the hypermethylated breast tumor gene signature identified in TCGA [35] overlapped with our cluster 3, showing both hypermethylation and reduced expression of genes such as ASCL2, CCND2, COL1A2, EPHB1, FABP3, GAS7, IFNGR2, IRAK3, KLK10, POMC, SCGB3A1, SFRP1, SMO, and VCAN (CSPG2). Here, SCGB3A1 is linked to breast neoplasm.