Higher tumor grade (II/III versus I), larger tumor size (<2 cm versus >2 cm), and increasing clinical stage (comparing across stages 1 to 4) were associated primarily with CpG hypermethylation; however, compared with HR status, subtype, or p53 status, fewer differentially methylated CpG loci were detected in association with these characteristics (177 CpGs for tumor grade, 24 CpGs for tumor size, and 14 for stage) (Figure 2B). The gene discussed is TP53; the disease is neoplasm.