Moreover, the hypermethylated breast tumor gene signature identified in TCGA [35] overlapped with our cluster 3, showing both hypermethylation and reduced expression of genes such as ASCL2, CCND2, COL1A2, EPHB1, FABP3, GAS7, IFNGR2, IRAK3, KLK10, POMC, SCGB3A1, SFRP1, SMO, and VCAN (CSPG2). The gene discussed is EPHB1; the disease is breast neoplasm.