Importantly, our findings are consistent with prior reports of heavier methylation among HR+ breast tumors, less methylation in basal-like tumors [35],[38],[39],[44], and significant correlation of breast tumor DNA methylation patterns with HR subtype [36],[45], gene expression-based subtype [35],[37],[39],[44],[46],[47], or p53 mutational status [37]. The gene discussed is TP53; the disease is breast neoplasm.