Eleven studies including 1171 SLE patients and 1834 controls described IL-1RN VNTR genotypes, seven studies including 1012 SLE patients and 2442 controls described ESR1 PvuII genotypes and six studies including 816 SLE patients and 1478 controls described ESR1 XbaI genotypes. The gene discussed is ESR1; the disease is systemic lupus erythematosus.