There was also an association between ESR1 PvuII and SLE in the dominant model (CC/CT vs. TT: OR = 1.25, 95% CI = 1.06–1.47, P = 0.01), which was pronounced among Asian individuals (CC/CT vs. TT: OR = 1.33, 95% CI = 1.04–1.69, P = 0.02). The gene discussed is ESR1; the disease is systemic lupus erythematosus.