Given the potentially important roles of these three polymorphisms in the pathological process and the increasing numbers of studies in different populations, we performed a meta-analysis to derive a more precise estimation of the associations between the IL1-RN VNTR, ESR1 PvuII, and ESR1 XbaI polymorphisms and SLE susceptibility. The gene discussed is IL1B; the disease is systemic lupus erythematosus.