Though IBD-susceptibility loci, such as nucleotide oligomerization domain 2 (NOD2), immunity-related GTPase family M (IRGM), interleukin 23 receptor (IL23R) and autophagy related 16-like 1 (ATG16L1), have been previously identified, their roles in the incidence of IBD remain controversial [10]–[13]. The gene discussed is IRGM; the disease is inflammatory bowel disease.