Specifically, exposure to TCDD did not affect mRNA levels of CTNNB1 target genes Axin2 and Lgr5 in the hepatoma cell line, nor did 3-methylcholanthrene (3MC, an AHR agonist) affect mRNA levels of the same two target genes in the liver [99]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.