AHR and neoplasm: Furthermore, I3C or 3,3'-diindolylmethane (DIM, an AHR agonist) delayed time to tumor development and reduced tumor multiplicity when added to the diet of Apcmin/+; Ahr+/+ or Apcmin/+; Ahr+/− mice, but these AHR agonists had no effect on tumor development in Apcmin/+; Ahr−/− mice.