CTNNB1 and hepatocellular carcinoma: In a mouse hepatoma cell line, TCDD activated expression of an AHR reporter gene (luciferase driven by a promoter containing three DREs) to a significantly greater extent in cells expressing a stabilized CTNNB1 (CTNNB1S33Y mutation) than in control cells expressing wild type CTNNB1 (Table 1) [110].