The canonical example, of course, is the use of imatinib in the treatment of chronic myelogenous leukemia harboring the BCR/ABL rearrangement [27].A more recent example is the remarkable success of BRAF inhibitors in the treatment of malignant melanomas with BRAF V600E mutations [28]. The gene discussed is BRAF; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.