In a series of over 3,000 patients with brain metastasis arising from breast cancer treated from 1989 to 2006, multivariate analysis indicated that triple negative status was the greatest risk factor for the development of cerebral metastasis (odds ratio=4.16; p<0.001), above that of HER2 positive status (OR=3.43; p=0.005) [21]. Here, ERBB2 is linked to breast carcinoma.