Consistent with previous findings in other types of human cancer [29,30], reduced LDHB and hnRNPF expressions were observedboth at the mRNA and protein levels in MCC-2 and MCC-3 cells following mTOR pathway inhibition, indicating that LDHB and hnRNPF are downstream effectors of mTOR pathway (Figure 5). The gene discussed is LDHB; the disease is cancer.