MAN1A1 and cancer: Figure 4 illustrates further that both Man9 (TM10) and Man9 (2G12) detected significantly increased amounts of IgG antibodies in sera from the PCa group compared to sera from the BPH group. The Man9 (TM10) conjugate is the most effective one in capturing serum IgGs among all autoantigens examined in this microarray analysis. In the context of tumor cell-surface expression of the TM10-antigens [24] and intensive expression of oligomannoses in the higher Gleason grade cancers [16], IgGMan9 appears to be an attractive serum biomarker for further investigation.