The serum level of HMGB1 is significantly higher in patients with low liver fibrosis (fibrosis score 1–2) compared to those with high liver fibrosis (fibrosis score 3–4), which is a non-invasive, repeatable, and convenient marker for distinguishing advanced fibrosis from low fibrosis in chronic hepatitis B virus patients [60]. Here, HMGB1 is linked to Hepatic fibrosis.