Early reports have demonstrated that antibodies to HMGB1 and HMGB2 are found in about 1/3 of SSc Sera and anti-HMGB1/HMGB2 antibodies are detected commonly in systemic rheumatic diseases, particularly in rheumatoid arthritis and SSc [43,44]. The gene discussed is HMGB2; the disease is rheumatoid arthritis.