Data from this study suggests that among patients with de novo CN-AML, particularly those <60 years, AMLDNMT3A/FLT3/NPM1 patients seem to have the worst clinical outcomes, followed by those with AMLFLT3/DNMT3A and then those with AMLNPM1/DNMT3A. Here, FLT3 is linked to acute myeloid leukemia.