In this study, we assess the clinical and outcome characteristics of patients with AMLDNMT3A/FLT3/NPM1 as an index group and compare them to those with de novo AML harboring other mutation combinations involving DNMT3A, FLT3 and/or NPM1 to further elucidate the clinical effects of these mutations when they occur concurrently. This evidence concerns the gene DNMT3A and acute myeloid leukemia.