DNMT3A and acute myeloid leukemia: Accordingly, we designed this study to investigate the clinical and outcome characteristics of patients with AMLDNMT3A/FLT3/NPM1 as an index group and compare them to those with de novo AML harboring other mutation combinations involving DNMT3A, FLT3 and/or NPM1. Since the incidence of AMLDNMT3A/FLT3/NPM1 is low, cases seen at our institution were combined with those in the TCGA data set to increase the statistical power of our analysis.