Accordingly, we designed this study to investigate the clinical and outcome characteristics of patients with AMLDNMT3A/FLT3/NPM1 as an index group and compare them to those with de novo AML harboring other mutation combinations involving DNMT3A, FLT3 and/or NPM1. Since the incidence of AMLDNMT3A/FLT3/NPM1 is low, cases seen at our institution were combined with those in the TCGA data set to increase the statistical power of our analysis. Here, NPM1 is linked to acute myeloid leukemia.