Apart from influencing arterial stiffness, MBL deficiency is also known to be associated with severe atherosclerosis[21] and doubles the risk for myocardial infarction (MI) in young relatively healthy Caucasians[22], and leads to cardiovascular events in type 2 diabetic South Asians[23]. This evidence concerns the gene MBL2 and hyperinsulinemic hypoglycemia, familial, 4.