BRCA1 and breast carcinoma: For example, the breast cancer susceptibility gene BRCA2 and the BRCA1-interacting protein BRIP1 are identified in every species studied except for the three protostomes D. melanogaster, C. elegans, and P. pacificus, with BRCA2 additionally being absent in L. gigantea; BRCA2 was previously identified to be well conserved in Nematostella [9].