CD4 and HIV infectious disease: Given that patients on monotherapy had a significantly longer time of known HIV infection and a lower CD4+ T lymphocyte count before starting cART and these variables could mean a bias to compare both groups, we repeated the analysis controlling both variables, excluding those patients on monotherapy with longer follow-up (more than 12 years, lower IQR of MPI group) and lower CD4+ T lymphocyte count previous to treatment (below 200 cells/mm3, median value of MPI group).