It was, however, influenced by the topic of the Dbox (P = 0.002; Figure 1): clinicians had the highest intention to use the Dbox on prenatal screening for trisomy 21, closely followed by prostate-specific antigen (PSA) testing for prostate cancer and cholinesterase inhibitors for Alzheimer’s disease (Table 5). Here, KLK3 is linked to early-onset autosomal dominant Alzheimer disease.