DHSGT treatment restored decreased PPAR-γ expression levels in the aorta of western diet-fed ApoE KO mice and the beneficial effect of DHSGT on endothelial dysfunction in diabetic atherosclerosis was similar to rosiglitazone (a PPARγ agonist) which is ameliorated in insulin sensitivity [14]. The gene discussed is PPARG; the disease is endothelial dysfunction.