ERBB2 and breast carcinoma: In all models, we observed a significant increase in the number of lung metastasis: 5.5 times higher in 202Mul mice (P <0.001), almost 12 times higher in mice with activated Neu (P = 0.02) and 6.7 times higher in mice with orthotopic implantation of mammary carcinoma cells (P = 0.01) (Figure 1F, 1G).