TGFB1 and neoplasm: In our previous research article it was indicated that deletion of TβRII in mammary epithelial of mouse mammary tumor virus (MMTV)-polyoma middle T antigen (PyMT) mice results in shortened tumor latency and a five-fold increase in lung metastases compared to MMTV-PyMT tumors with intact TGFβ signaling [5],[6].