Increased tumor latency in MMTV-Neu/DNIIR mice (202Mul/DN, NK1Mul/DN) versus control mice (202Mul, NK1Mul) could be first due to cell-cycle dysregulation, where TGFβ signaling plays an important role, and second, due to dysregulation of chemokine expression. This evidence concerns the gene TGFB1 and neoplasm.