Our findings demonstrate that the G/C heterozygous genotype in the TIMP-2-418G>C (rs8179090) promoter, MMP-2 -1575GA/-1306CC, and the dominant type (GG vs. GA + AA) of MMP-9 Q279R (rs17576) could be genetic predisposing factors for MMD development. This evidence concerns the gene MMP2 and multiminicore myopathy.