Expression of ZAP-70, CD38, and ITGA4 significantly correlated in CLL (R = 0.512 for ZAP-70 and CD38, R = 0.509 for ZAP-70 and ITGA4, and R = 0.393 for CD38 and ITGA4); and in general, also correlated similarly with the IL-4 targets (e.g., positive correlations with SUSD2, CABIN1, OBFC2A, SLC5A12, SLC37A3, PLD6, or negative correlations with EVI2A), though the number of IL-4 targets significantly correlated with ZAP-70 was higher than with CD38 or ITGA4 (Table S10). The gene discussed is PLD6; the disease is B-cell chronic lymphocytic leukemia.