Many of the genes significantly overexpressed (e.g. ABCA6, FMOD, IGFBP4, IGSF3, LEF1, RASGRF1, RHOC, ROR1, WNT3), or underexpressed (e.g. EBF1, HIF1A, IQSEC1, KLF3, MS4A1, SIPA1, TRIB2, TUBB1, VAV3, ZBTB16) in CLL, were concordant with previous studies, thereby providing proof of the validity of our microarray study. The gene discussed is ZBTB16; the disease is B-cell chronic lymphocytic leukemia.