Of them, FOS, FOSB, DUSP1, CEBPD, and ITGB2 were more than 5-fold downregulated in both cell types, GZMA and JUN had stronger downregulation in CLL (indeed, JUN was one of the IL-4 targets (Table S3)), and MYLK, PRKAR2B, SELP, FHL2, JUND, SMPD3, and CLDN5, in NBC. The gene discussed is SMPD3; the disease is B-cell chronic lymphocytic leukemia.