ZAP70 and B-cell chronic lymphocytic leukemia: In contrast to the study of Coscia and co-workers [23] which reports lower sensitivity to spontaneous apoptosis of CLL cells expressing poor prognosis markers, we did not observe significant differences in sensitivity of ZAP-70 positive and negative patients, despite differential regulation of several apoptosis-related IL-4 targets (SOCS1, NFKBIZ, LNPEP, RPS6KA2).