In addition, CAMKK1 and ESR2 were upregulated by cell culture but recovered their baseline levels by IL-4 in CLL (Table S8), and GNG4 and HRK were upregulated, and JAK2 was downregulated by cell culture, but their levels were stabilized by IL-4 in NBC (Table S9). This evidence concerns the gene IL4 and B-cell chronic lymphocytic leukemia.