Many of the genes significantly overexpressed (e.g. ABCA6, FMOD, IGFBP4, IGSF3, LEF1, RASGRF1, RHOC, ROR1, WNT3), or underexpressed (e.g. EBF1, HIF1A, IQSEC1, KLF3, MS4A1, SIPA1, TRIB2, TUBB1, VAV3, ZBTB16) in CLL, were concordant with previous studies, thereby providing proof of the validity of our microarray study. This evidence concerns the gene IGSF3 and B-cell chronic lymphocytic leukemia.