Many of the genes significantly overexpressed (e.g. ABCA6, FMOD, IGFBP4, IGSF3, LEF1, RASGRF1, RHOC, ROR1, WNT3), or underexpressed (e.g. EBF1, HIF1A, IQSEC1, KLF3, MS4A1, SIPA1, TRIB2, TUBB1, VAV3, ZBTB16) in CLL, were concordant with previous studies, thereby providing proof of the validity of our microarray study. Here, LEF1 is linked to B-cell chronic lymphocytic leukemia.