Figure 2 shows the cumulative rates of survival for patients with coexisting AKI admitted to ICU were dichotomized at 10 SOFA points or less, and more than 11 SOFA points (p<0.001). To evaluate the correlation among APACHE II, APACHE III, SOFA score and various severity of AKI, we compared the means between groups according to the RIFLE classification by using ANOVA. The chi-square for trends revealed that the APACHE II, APACHE III, SOFA score were all significantly different between non-AKI and AKI groups with varying severity (P<0.001) (Figure 3). The gene discussed is BTBD8; the disease is acute kidney injury.