Supporting this observation, we find that both Deeply shared and human only CRMs overlap significantly with relevant ENCODE genome-wide experimental data sets, including ChIP peaks for HNF4A, FOXA1, and CEBPB in the liver cancer cell line HepG2 (e.g., p < 10−149 and p < 10−212 for HNF4 respectively; Supplementary file 1). Here, HNF4A is linked to liver cancer.