Finally, also markers involved in Treg function such as CTLA-4 (Fig. 3G) and FOXP3 (Fig. 3H) were similarly regulated by 1,25(OH)2D3 or TX527 in T cells from patients with type 1 diabetes after additional proinflammatory cytokine stimulation. This evidence concerns the gene FOXP3 and type 1 diabetes mellitus.