It is also important in the context of type 1 diabetes, which is associated with IFN-γ producing Th1 cells, IL-17A producing Th17 cells and an increase in IL-9+IL-17+ cells, that exposure of T cells from type 1 diabetes donors to 1,25(OH)2D3 and TX527 reduced production of all tested helper T cell cytokines. The gene discussed is IL17A; the disease is type 1 diabetes mellitus.