In vivo, IL-10 was identified as an essential component for vitamin D-mediated inhibition of experimental autoimmune encephalomyelitis [41] and in vitro, vitamin D-induced IL-10-producing Tregs were able to prevent the induction of experimental autoimmune encephalomyelitis in an IL-10 dependent way [40]. The gene discussed is IL10; the disease is experimental autoimmune encephalomyelitis.