This work also clarifies why deficiencies in this enzyme would be associated with loss of functional glycosylation and laminin binding of α-dystroglycan and be causal for congenital muscular dystrophy (Bao et al., 2009; Buysse et al., 2013; Czeschik et al., 2013; Shaheen et al., 2013). The gene discussed is LAMB2; the disease is congenital muscular dystrophy.