These researchers then discovered that the mesothelioma cells were generating more superoxide than the normal mesothelial cells – via Nox4 activity, as well as mitochondrial activity – and that measures which suppressed superoxide production in the mesothelioma (apocynin, rotenone, and Nox4 anti-sense) all markedly protected the cancer cells from ascorbate exposure. Here, NOX4 is linked to cancer.