Administration of propolis to mouse models of DM suggests homeostasis maintenance, so that further activated cell can be controlled by involving regulatory T cells from both CD4 and CD8 T cells (Oršolić and Bašić2008; Yue et al.2003; Obrosova et al.2003; Sforcin and Bankova2011; Sawicka et al.2012; Rifa’i et al.2004; Lee et al.2008). Here, CD4 is linked to diabetes mellitus.