BDNF and early-onset autosomal dominant Alzheimer disease: That fine-tuning of BDNF levels via its 3’UTR has physiological and clinical importance is illustrated by a recent study by Lee et al., where anti-miR based knock-down of miR-206, a negative regulator of BDNF, increased endogenous BDNF levels and alleviated Alzheimer’s disease in a mouse model (Lee et al. 2012).