When combined, the odds ratio for prostate cancer for patients with high hK2 levels and the variant T-allele of rs198977 was 3.77 (95% CI: 1.94-7.32, p < 0.0001), compared to patients with low hK2 levels and the C-allele (Table 4).We incorporated hK2 level and KLK2 SNPs to construct a nomogram for calculating the probability of a prostate cancer, and in particular, for ≥ Gleason 7 prostate cancer on repeat biopsy (Figure 1). This evidence concerns the gene HK2 and Familial prostate cancer.