Comparison of EVs derived from a highly metastatic rat pancreatic adenocarcinoma cell line expressing Tspan8 with its wild-type counterpart suggests that Tspan8 contributes to a selective recruitment of proteins into EVs, including VCAM-1 and the integrin alpha4, which were involved in EV–EC binding and internalization (102). This evidence concerns the gene TSPAN8 and pancreatic adenocarcinoma.