SLC6A3 and obesity due to melanocortin 4 receptor deficiency: With these studies in favor of an association of dopaminergic gene polymorphisms and even a study showing that methamphetamine known to block DAT1 reducing fat and carbohydrate intake (Danilovich et al., 2014), there is real controversy concerning the actual role of BMI as a biological marker for obesity relative to percent body fat, as clearly pointed out by Shah and Braverman (2012).