Ischemic death of CA1 neurons was also prevented in a KI mouse containing a form of Bcl-xL resistant to caspase/calpain cleavage (Ofengeim et al., 2012) confirming the specific role of ΔN Bcl-xL in the onset of cell death in hippocampal CA1 neurons during global ischemic brain injury. Here, BCL2L1 is linked to brain injury.