Many of the signaling kinases, including Akt/protein kinase B (PKB), protein kinase C-ε (PKC-ε), and extracellular regulated kinases (ERK1/2), translocate to mitochondria to contribute to the acute memory phase in cytoprotection against the impending index ischemia that can lead to heart damage (Zaugg and Schaub, 2003). The gene discussed is AKT1; the disease is ischemia.