MME and amyloidosis: Viral gene delivery of NEP to the brain of AD transgenic mice also was shown to reduce amyloid pathology (Marr et al., 2003) and subsequent studies, including the application of a recombinant, brain-targeted NEP (Spencer et al., 2014), have confirmed and extended these observations on the critical nature of NEP to amyloid clearance (Leissring et al., 2003).